NFL Weekly Preview Week 10 2025: Key Injuries, Difference Makers & Projected Upsets

We begin the 10th week of the 2025 NFL regular season on Thursday. Here are the key injuries, fantasy stars and projected upsets.

Key Injuries

There were several significant week nine injuries. Those players not available for Week 10 and the rest of the season are Green Bay Packers tight end Tucker Kraft (torn anterior cruciate ligament), San Francisco 49ers defensive lineman Mykel Williams (torn ACL and torn lateral meniscus), Washington Commanders wide receiver Luke McCaffrey (broken collarbone), Commanders cornerback Marshon Lattimore (torn ACL), and Buffalo Bills defensive lineman Mike Hoecht (torn Achilles). Meanwhile, Commanders quarterback Jayden Daniels is expected to be out long term with a dislocated elbow.

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Fantasy Stars

The top rated quarterback is Josh Allen of the Buffalo Bills. He is projected to get 229 yards passing, 35 yards rushing and two touchdowns on Sunday against the Miami Dolphins. The top rated wide receiver is Jaxon Smith-Njigba of the Seattle Seahawks. He is expected to get eight catches for 103 receiving yards and a touchdown on Sunday against the Arizona Cardinals. The top rated running back is Christian McCaffrey of the San Francisco 49ers. As the focal point of the 49ers offense against the Los Angeles Rams in this intriguing battle of California, McCaffrey is projected to get 116 total yards (65 yards rushing and 51 yards receiving) and one touchdown.

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Projected Upset

I only like one upset this week. That is the Jacksonville Jaguars to beat the Houston Texans. The Houston quarterback, CJ Stroud will not be playing due to a concussion. That puts the Jaguars offense at an advantage.

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